regeneron
Seattle, WA, USA
We are seeking a highly motivated Scientist to join our Research team within Regeneron Cell Medicine. You will help support our automation pipeline to drive medium to high throughput CAR-T and TCR binder triage and binder optimization experiments forward. We hope you are excited by the opportunity to help advance the next generation of cell therapies. As a Scientist, a typical day might include: Using Hamilton Vantage liquid handlers to drive medium to small scale T-Cell expansions Designing and cloning CAR/TCR constructs into lentiviral vectors Generating LVV in a high throughput manner to drive binder triage experiment Engineering T cells with CARs or TCRs using lentiviral vectors Performing in-vitro immunological assays such as T-Cell cocultures, cytotoxicity, and immunophenotyping by flow cytometry Assisting in the development of an improved TCR based off target derisking platform utilizing cell-based assays Setting up and performing in depth...