Executive Director, Pricing Strategy, Analytics & Contracting

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

The Executive Director, Pricing Strategy, Analytics & Contracting (Global Impact) is a critical leader within Global Market Access responsible for shaping and executing U.S. pricing and contracting strategy while proactively assessing global price dynamics that can influence U.S. net price and profitability. This role leads a small team and serves as a strategic partner across Finance, Forecasting, Business Operations, Legal/Compliance, Government Affairs and Market Access to drive disciplined deal analytics, ROI/profitability optimization, and pricing governance in a rapidly changing policy and competitive environment.

This leader combines forward-looking strategic insight (scenario planning for IRA and evolving reference pricing dynamics, competitive entrants, policy shifts) with hands-on operational leadership (customer deal analytics, contracting execution, GTN management, and government pricing oversight via vendor partners).

Key Responsibilities

Pricing Strategy, Policy, and Governance

• Establish and evolve U.S. pricing strategy and pricing policy frameworks aligned with enterprise objectives and market access strategy.
• Develop and maintain a pricing “playbook” and decision frameworks (price corridors, leverage points, governance) to standardize pricing and contracting decisions across channels.
• Lead pricing governance forums (e.g., pricing committee) and ensure clear decision rights and escalation pathways for complex pricing decisions.
• Ensure pricing recommendations align with applicable regulations, public policy guidance, and internal legal/compliance standards.

Deal Analytics, ROI, and Profitability Optimization

• Lead analytical support for strategic customer deals, including ROI assessment, profitability modeling, scenario evaluation, and negotiation support.
• Build and refine pricing and contracting models incorporating discounts/rebates, volume assumptions, channel dynamics, and competitive context to evaluate GTN and profitability impact.
• Provide actionable insights to leadership on trade-offs and value optimization across payer segments and contract constructs.

Market & Policy Impact Assessment (US + Global Interdependencies)

• Monitor and assess evolving policy and market dynamics impacting U.S. pricing and access, including IRA-related considerations and other reference pricing constructs (e.g., MFN/MRP), and implications of ex-U.S. price changes on U.S. price strategy.
• Develop forward-looking scenarios for competitive entrants and access controls; quantify risk/opportunity and recommend mitigation strategies.
• Partner cross-functionally to translate policy and market shifts into pricing actions and risk management plans.

Contracting Operations & Performance Management

• Oversee end-to-end contract lifecycle strategy and execution, including offer evaluation, financial modeling, negotiation support, execution, and ongoing performance monitoring.
• Monitor payer/GPO/specialty/pharmacy and health system contract performance to optimize GTN and profitability by channel.
• Partner with internal stakeholders and vendors to ensure accurate implementation of pricing changes and operational processes (e.g., chargeback price updates, rebate workflows).

Gross-to-Net (GTN) Leadership

• Provide leadership and oversight for GTN analytics to support forecasting, budgeting, and monthly close activities.
• Identify key drivers of GTN variance and recommend actions to minimize revenue leakage and improve performance across programs and channels.
• Collaborate closely with Finance and Forecasting to ensure disciplined accrual methodology and clear communication of GTN impacts.

Government Pricing Oversight & Compliance (via Vendor Management)

• Oversee vendor-managed government price calculations and reporting processes (e.g., AMP, BP, ASP and related requirements), including validation, review, and timely submissions.
• Partner with Legal/Compliance to monitor legislative/regulatory changes and ensure governance processes remain current and audit-ready.
• Ensure operational controls and documentation support compliance expectations.

People Leadership & Cross-Functional Influence

• Lead, coach, and develop a high-performing team; set clear goals, elevate capabilities, and foster strong accountability.
• Serve as a highly collaborative partner across Finance, Forecasting, Business Operations, Legal/Compliance, and Market Access functions.
• Communicate complex analyses clearly to senior stakeholders; influence decisions with data-driven narratives and recommendations.

Qualifications

Required

• Bachelor’s degree in Business, Finance, Economics, or related field.
• 15+ years of experience in U.S. pricing, contracting, market access, GTN, and/or related commercial analytics within pharmaceutical/biotech.
• Demonstrated experience leading teams and developing talent.
• Deep expertise in financial modeling, pricing/contract scenario analysis, and GTN drivers across channels.
• Strong understanding of the evolving U.S. pricing and access environment, including policy-driven impacts (e.g., IRA considerations) and implications of broader reference pricing dynamics.
• Proven ability to lead complex cross-functional workstreams, influence without authority, and drive decision-making in a fast-moving environment.
• Excellent communication skills with executive presence and strong business judgment.

Preferred

• MBA or other advanced degree.
• Experience assessing international pricing interdependencies and ex-U.S. impacts on U.S. pricing strategy.
• Experience designing or evolving pricing governance frameworks and contracting authority structures.

Madrigal offers a competitive Total Rewards strategy to attract and retain top talent and is inclusive of base pay, bonus, equity, and a generous benefits package. Full-time employees are eligible for base salary, bonus, equity, and a comprehensive benefits suite. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs, and market demands.

As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $283,300- $346,300 per year. We comply with all applicable minimum wage laws.

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.  

Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. 

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact HR@madrigalpharma.com. 

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. 

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. 

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. 

Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.  

Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to HR@madrigalpharma.com.